[ Instrument network instrument research and development ] Recently, the Institute of Precision Measurement Science and Technology Innovation of the Chinese Academy of Sciences and Wuhan University have developed a new method for enhancing gas magnetic resonance signals in aqueous solutions. This method can significantly enhance gas magnetic resonance signals in aqueous solutions. Thereby improving the sensitivity of magnetic resonance molecular detection. The relevant research results were published in the Proceedings of the National Academy of Sciences (PNAS).
Magnetic resonance spectroscopy and imaging (NMR/MRI), as an important analysis and medical imaging technology, has been widely used in the detection of liquids, solids, and biological tissues. It has become one of the imaging technologies to display the structure and function of the human body in a living state. It can image solid organs without radiation and imaging depth limitation. However, for the lungs, traditional magnetic resonance imaging (1H MRI) technology is difficult to image the gas in the alveoli, so the lungs have become a "blind spot" in traditional magnetic resonance detection.
Gas magnetic resonance can make up for the shortcomings of traditional magnetic resonance. Zhou Xin's research group from the Institute of Precision Measurement and Measurement used hyperpolarization technology to enhance the 129Xe gas magnetic resonance signal by more than 50,000 times, and it has been applied to the detection of human lung structure and function, successfully "lighting up" the lung. This technology is not invasive and has advantages that other technologies cannot match in the diagnosis and treatment evaluation of major lung diseases. However, there is no specificity in using 129Xe MRI directly for biological system detection. In recent years, a series of molecular "cages" have been developed internationally, which can bind 129Xe atoms and endow the hyperpolarized 129Xe magnetic resonance with specific detection capabilities. However, these molecular "cages" have poor water solubility and the problem of weak 129Xe signal in the "cage". Improving the signal strength of 129Xe in the "cage" is a major challenge in this field.
In this study, the researchers first proposed a water-stable metal organic framework material (MOF)-ZIF-8 as a 129Xe nano-cage to load 129Xe, which can effectively increase the concentration of 129Xe in the "cage" in the aqueous solution. The hyperpolarized gas magnetic resonance scientific instrument independently developed by the group significantly enhanced the magnetic resonance signal of 129Xe in the "cage" in the aqueous solution, which was 200 times higher than the magnetic resonance signal of 129Xe in the traditional molecular "cage", and achieved hyperpolarization. An important breakthrough in the field of 129Xe magnetic resonance molecular imaging. In addition, because the barrier of Xe signal strength in the "cage" is broken, the chemical exchange between the signal and the signal in the blood can be used in biological testing to amplify the weak signal in the blood, thereby enhancing the sensitivity of molecular detection in the blood.
This method is named "Hyperpolarized Xe Signal Advancement by Metal-organic framework Entrapment (Hyper-SAME)". Hyper-SAME can be combined with the Hyper-SAGE technology (PNAS, 2009) previously invented by the author to further optimize and amplify the 129Xe magnetic resonance signal. This research has significantly improved the sensitivity and resolution of gas magnetic resonance in aqueous solutions, and represents a step towards high-sensitivity targeted detection of gas magnetic resonance as a major biomedical tool.
Dr. Zeng Qingbin of the Institute of Precision Measurement and Dr. Binglin Binglin of Wuhan University are the co-first authors. Researchers of the Institute of Precision Measurement, Zhou Xin, Guo Qianni and Professor Deng Hexiang of Wuhan University are the co-corresponding authors. The research was supported by the Ministry of Science and Technology, the National Natural Science Foundation of China and the Chinese Academy of Sciences.
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