In recent years, China's pharmaceutical industry has achieved long-term development. GMP's drug regulations expressly state that all pharmaceutical equipment must comply with GMP production requirements and must be capable of in-situ cleaning and in-situ sterilization. During the operation of the equipment, there must be no secondary pollution to the medicine.
In response to this requirement, a company uses a positive pressure drying process for low-energy aseptic spray drying equipment. 0.5u of dust particles in the hot air entering the tower does not exceed 10/liter. Operating temperature can be 0--150 °C, using a three-fluid nozzle. The vapor-liquid contact is good and the atomization is even, which meets the aseptic operation requirements. Due to the good vapor mist contact and short drying time, the dry strength can reach about 7 kg (water)/m3?
In order to better reduce costs, increase production efficiency, and reduce the labor intensity of workers in the pharmaceutical process, according to foreign technical data, in 2000 it developed its own filtration, washing, and drying "triple play" equipment. The equipment can complete filtration, washing (bleeding), and drying in a sealed container. At the same time, it replaces filtration and drying equipment. It can achieve continuous operation in the whole closed and full process, and is more suitable for products requiring asepsis. The production of toxic products.
In the filtration stage, the crystal and the mother liquor are separated and operated under pressurized vacuum conditions. The smoothing and compaction of the filter cake through the smoothing of the S-type stirring paddles makes the solid-liquid separation effect better. A special rotating spray device is arranged in the container so that the cleaning liquid is evenly distributed in the container. The internal cleaning of the container and the cleaning of the material can be achieved. Through the rotation and lifting of the stirring blades, the filter cake and the cleaning liquid are mixed more uniformly. The slurry cake was thoroughly washed. The filter cake after suction filtration is scraped and heated by the stirring slurry layer by layer to heat the entire barrel body, the chassis, and the blade to scrape the material. The side discharge device is opened, and the material is automatically discharged from the discharge port on the side of the tank wall through the pushing of the blade.
In order to reduce the investment of equipment and equipment processes in the processing of pharmaceuticals, the company has developed a “five-in-one†device based on double cones, ie, five processes of crystallization, reaction, filtration, washing, and drying in a single device. . One end of the double cone is designed as a circular arc bottom and a stirring blade is designed. In the reaction and crystallization, the cone faces downward, and uniform crystallization and reaction are achieved by stirring the stirring leaves. After crystallization, reaction, the cone was rotated 180°C.
At one end of the cone is designed a filter sintered mesh device. After the suction filter is connected, the mother liquor is filtered and the washing solution is passed through the washing interface. The filter cake is washed during the revolving process. After the washing process is completed, as in the double-cone drying process, in order to prevent the material from pilling, the stir-leaf can also be used to start smashing the material. After drying, open the end cap discharge (same double cone) and clean the material at one time. Therefore, this kind of equipment is more practical and combines the advantages of the tank type three-in-one and double-cone.
Spray drying equipment development direction
In the field of spray dryers, our country has developed new types of devices that are required by the objective market. The common feature of these devices is that instead of using a single spray dryer as a commercial product, a spray dryer is used as the core, and according to the characteristics of the materials, other drying devices or auxiliary equipment combined drying equipment systems are used to make their final products meet User needs. In addition, the basic trend of large-scale, high-strength, high economical, and spray dryer development to improve the adaptability of raw materials and product quality. At the same time, the development of spray dryers should pay attention to the comprehensive utilization of energy-saving and energy, as well as the development of dryer automatic control technology, in order to ensure the realization of the best operating conditions. In addition, as a human being attaches great importance to environmental protection, improved spray dryers to reduce dust and exhaust gas leakage environmental protection measures will also be studied in the depth direction.
Precision Plastic Injection Parts
Plastic injection parts can be seen everywhere in industry and in daily life, and can be said to be the most used parts by humans. All industries such as automobiles, airplanes, ships, electrical and electronic, etc. will use more or less precision plastic injection molding parts, and even our daily washbasins, tooth cups, plastic chairs, power sockets, etc. are plastic injection molding parts. Its biggest feature is that it is widely used, high efficiency, low cost, and high product precision. However, since precision molds are required to form products before production, mold costs and mold opening time need to be invested in the early stage, which is not suitable for small batches of products. Moreover, the development of precision molds is very critical. Only by producing high-precision and durable molds can the accuracy and production efficiency of subsequent products be guaranteed. Therefore, the development of plastic molds is very important for the production of plastic injection parts.
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